Astroglial Ca(2+)-Dependent Hyperexcitability Requires P2Y(1) Purinergic Receptors and Pannexin-1 Channel Activation in a Chronic Model of Epilepsy

Astrocytes from the hippocampus of chronic epileptic rats exhibit an abnormal pattern of intracellular calcium oscillations, characterized by an augmented frequency of long lasting spontaneous Ca(2+) transients, which are sensitive to purinergic receptor antagonists but resistant to tetrodotoxin. Th...

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Detalles Bibliográficos
Autores principales: Wellmann, Mario, Álvarez-Ferradas, Carla, Maturana, Carola J., Sáez, Juan C., Bonansco, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277884/
https://www.ncbi.nlm.nih.gov/pubmed/30542266
http://dx.doi.org/10.3389/fncel.2018.00446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277884/
https://www.ncbi.nlm.nih.gov/pubmed/30542266
http://dx.doi.org/10.3389/fncel.2018.00446

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