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Astroglial Ca(2+)-Dependent Hyperexcitability Requires P2Y(1) Purinergic Receptors and Pannexin-1 Channel Activation in a Chronic Model of Epilepsy

Astrocytes from the hippocampus of chronic epileptic rats exhibit an abnormal pattern of intracellular calcium oscillations, characterized by an augmented frequency of long lasting spontaneous Ca(2+) transients, which are sensitive to purinergic receptor antagonists but resistant to tetrodotoxin. Th...

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Detalles Bibliográficos
Autores principales:	Wellmann, Mario, Álvarez-Ferradas, Carla, Maturana, Carola J., Sáez, Juan C., Bonansco, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277884/ https://www.ncbi.nlm.nih.gov/pubmed/30542266 http://dx.doi.org/10.3389/fncel.2018.00446

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