Purinergic targeting enhances immunotherapy of CD73(+) solid tumors with piggyBac-engineered chimeric antigen receptor natural killer cells

BACKGROUND: The anti-tumor immunity of natural killer (NK) cells can be paralyzed by the CD73-induced generation of immunosuppressive adenosine from precursor ATP within the hypoxic microenvironment of solid tumors. In an effort to redirect purinergic immunosuppression of NK cell anti-tumor function...

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Detalles Bibliográficos
Autores principales: Wang, Jiao, Lupo, Kyle B., Chambers, Andrea M., Matosevic, Sandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278070/
https://www.ncbi.nlm.nih.gov/pubmed/30514403
http://dx.doi.org/10.1186/s40425-018-0441-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278070/
https://www.ncbi.nlm.nih.gov/pubmed/30514403
http://dx.doi.org/10.1186/s40425-018-0441-8

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