Exploratory evaluation of pharmacodynamics, pharmacokinetics and safety of rivaroxaban in children and adolescents: an EINSTEIN-Jr phase I study

BACKGROUND: The EINSTEIN-Jr program will evaluate rivaroxaban for the treatment of venous thromboembolism (VTE) in children, targeting exposures similar to the 20 mg once-daily dose for adults. METHODS: This was a multinational, single-dose, open-label, phase I study to describe the pharmacodynamics...

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Detalles Bibliográficos
Autores principales: Kubitza, Dagmar, Willmann, Stefan, Becka, Michael, Thelen, Kirstin, Young, Guy, Brandão, Leonardo R., Monagle, Paul, Male, Christoph, Chan, Anthony, Kennet, Gili, Martinelli, Ida, Saracco, Paola, Lensing, Anthonie W. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278122/
https://www.ncbi.nlm.nih.gov/pubmed/30534007
http://dx.doi.org/10.1186/s12959-018-0186-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278122/
https://www.ncbi.nlm.nih.gov/pubmed/30534007
http://dx.doi.org/10.1186/s12959-018-0186-0

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