Synthesis of Novel FTY720 Analogs with Anticancer Activity through PP2A Activation

FTY720 inhibits various cancers through PP2A activation. The structure of FTY720 is also used as a basic structure for the design of sphingosine kinase (SK) inhibitors. We have synthesized derivatives using an amide chain in FTY720 with a phenyl backbone, and then compounds were screened by an MTT c...

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Detalles Bibliográficos
Autores principales: Shrestha, Jitendra, Ki, Sung Hwan, Shin, Sang Mi, Kim, Seon Woong, Lee, Joo-Youn, Jun, Hee-Sook, Lee, Taeho, Kim, Sanghee, Baek, Dong Jae, Park, Eun-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278267/
https://www.ncbi.nlm.nih.gov/pubmed/30355990
http://dx.doi.org/10.3390/molecules23112750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278267/
https://www.ncbi.nlm.nih.gov/pubmed/30355990
http://dx.doi.org/10.3390/molecules23112750

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