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E46K Mutant α-Synuclein Is Degraded by Both Proteasome and Macroautophagy Pathway
Genetic studies have revealed that rare mutations and multiplications of the gene locus in α-synuclein (α-syn) are implicated in the pathogenesis of Parkinson’s disease (PD). However, the pathological effects of α-syn are still obscure. The neurotoxicity of α-syn is mainly determined by its protein...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278282/ https://www.ncbi.nlm.nih.gov/pubmed/30388770 http://dx.doi.org/10.3390/molecules23112839 |