2-(4-Methylsulfonylphenyl)pyrimidines as Prospective Radioligands for Imaging Cyclooxygenase-2 with PET—Synthesis, Triage, and Radiolabeling

Cyclooxygenase 2 (COX-2) is an inducible enzyme responsible for the conversion of arachidonic acid into the prostaglandins, PGG2 and PGH2. Expression of this enzyme increases in inflammation. Therefore, the development of probes for imaging COX-2 with positron emission tomography (PET) has gained in...

Descripción completa

Detalles Bibliográficos
Autores principales: Cortes-Salva, Michelle Y., Shrestha, Stal, Singh, Prachi, Morse, Cheryl L., Jenko, Kimberly J., Montero Santamaria, Jose A., Zoghbi, Sami S., Innis, Robert B., Pike, Victor W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278313/
https://www.ncbi.nlm.nih.gov/pubmed/30400142
http://dx.doi.org/10.3390/molecules23112850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278313/
https://www.ncbi.nlm.nih.gov/pubmed/30400142
http://dx.doi.org/10.3390/molecules23112850

Ejemplares similares