Cargando…

2-(4-Methylsulfonylphenyl)pyrimidines as Prospective Radioligands for Imaging Cyclooxygenase-2 with PET—Synthesis, Triage, and Radiolabeling

Cyclooxygenase 2 (COX-2) is an inducible enzyme responsible for the conversion of arachidonic acid into the prostaglandins, PGG2 and PGH2. Expression of this enzyme increases in inflammation. Therefore, the development of probes for imaging COX-2 with positron emission tomography (PET) has gained in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cortes-Salva, Michelle Y., Shrestha, Stal, Singh, Prachi, Morse, Cheryl L., Jenko, Kimberly J., Montero Santamaria, Jose A., Zoghbi, Sami S., Innis, Robert B., Pike, Victor W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278313/ https://www.ncbi.nlm.nih.gov/pubmed/30400142 http://dx.doi.org/10.3390/molecules23112850

Ejemplares similares

PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study
por: Shrestha, Stal, et al.
Publicado: (2020)

Development of N-Methyl-(2-arylquinolin-4-yl)oxypropanamides as Leads to PET Radioligands for Translocator Protein (18 kDa)
por: Brouwer, Chad, et al.
Publicado: (2014)

Region- and voxel-based quantification in human brain of [(18)F]LSN3316612, a radioligand for O-GlcNAcase
por: Lee, Jae-Hoon, et al.
Publicado: (2021)

In vivo evaluation of a novel (18)F-labeled PET radioligand for translocator protein 18 kDa (TSPO) in monkey brain
por: Yan, Xuefeng, et al.
Publicado: (2023)

Population-Based Input Function Modeling for [(18)F]FMPEP-d (2), an Inverse Agonist Radioligand for Cannabinoid CB(1) Receptors: Validation in Clinical Studies
por: Zanotti-Fregonara, Paolo, et al.
Publicado: (2013)

Candidate 3-benzazepine-1-ol type GluN2B receptor radioligands ((11)C-NR2B-Me enantiomers) have high binding in cerebellum but not to σ1 receptors
por: Cai, Lisheng, et al.
Publicado: (2023)

Fluorine-18 Labelled Radioligands for PET Imaging of Cyclooxygenase-2
por: Kaur, Jatinder, et al.
Publicado: (2022)

Human Biodistribution and Dosimetry of (11)C-CUMI-101, an Agonist Radioligand for Serotonin-1A Receptors in Brain
por: Hines, Christina S., et al.
Publicado: (2011)

(11)C-LY2428703, a positron emission tomographic radioligand for the metabotropic glutamate receptor 1, is unsuitable for imaging in monkey and human brains
por: Zanotti-Fregonara, Paolo, et al.
Publicado: (2013)

Synthesis and Evaluation of Translocator 18 kDa Protein (TSPO) Positron Emission Tomography (PET) Radioligands with Low Binding Sensitivity to Human Single Nucleotide Polymorphism rs6971
por: Zanotti-Fregonara, Paolo, et al.
Publicado: (2014)

Neuroinflammation in frontotemporal lobar degeneration revealed by (11)C‐PBR28 PET
por: Kim, Min-Jeong, et al.
Publicado: (2019)

(18)F-Radiolabeled Translocator Protein (TSPO) PET Tracers: Recent Development of TSPO Radioligands and Their Application to PET Study
por: Luu, Truong Giang, et al.
Publicado: (2022)

Development of a non-radiometric method for measuring the arterial input function of a (11)C-labeled PET radiotracer
por: Shetty, H. Umesha, et al.
Publicado: (2020)

Metal-Based PSMA Radioligands
por: Gourni, Eleni, et al.
Publicado: (2017)

[O-methyl-(11)C]N-(4-(4-(3-Chloro-2-methoxyphenyl)-piperazin-1-yl)butyl)-1H-indole-2-carboxamide ([(11)C]BAK4-51) Is an Efflux Transporter Substrate and Ineffective for PET Imaging of Brain D(3) Receptors in Rodents and Monkey
por: Liow, Jeih-San, et al.
Publicado: (2018)

Method development, validation, and impurity measurement of β-estradiol from radiolabeled [(131)I]β-estradiol using radio-high-performance liquid chromatography for radioligand of saturation binding assay
por: Daruwati, Isti, et al.
Publicado: (2023)

Editorial: Response assessment of radioligand therapies
por: Lopci, Egesta, et al.
Publicado: (2022)

PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects
por: Richards, Erica M., et al.
Publicado: (2018)

Radiolabeled Bombesin Analogs
por: Mansi, Rosalba, et al.
Publicado: (2021)

Radiolabeled PSMA Inhibitors
por: Neels, Oliver C., et al.
Publicado: (2021)

Cyclooxygenase-2 in Endometriosis
por: Lai, Zhen-Zhen, et al.
Publicado: (2019)

Radiosynthesis and Preclinical Evaluation of [(18)F]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats
por: Keller, Thomas, et al.
Publicado: (2017)

Radioligands Targeting Fibroblast Activation Protein (FAP)
por: Lindner, Thomas, et al.
Publicado: (2021)

Pharmacological Optimization of PSMA-Based Radioligand Therapy
por: van der Gaag, Suzanne, et al.
Publicado: (2022)

Commercial and business aspects of alpha radioligand therapeutics
por: Ostuni, Emanuele, et al.
Publicado: (2023)

Peptide Radioligands in Cancer Theranostics: Agonists and Antagonists
por: Nock, Berthold A., et al.
Publicado: (2023)

Novel Benzo[4,5]imidazo[1,2-a]pyrimidine derivatives as selective Cyclooxygenase-2 Inhibitors: Design, synthesis, docking studies, and biological evaluation
por: Bayanati, Maryam, et al.
Publicado: (2023)

Design, synthesis, docking, and anticancer evaluations of new thiazolo[3,2-a] pyrimidines as topoisomerase II inhibitors
por: El-Zoghbi, Mona S., et al.
Publicado: (2023)

The cyclooxygenases
por: Chandrasekharan, NV, et al.
Publicado: (2004)

Molecular Docking and Fluorescence Characterization of Benzothieno[3,2-d]pyrimidin-4-one Sulphonamide Thio-Derivatives, a Novel Class of Selective Cyclooxygenase-2 Inhibitors
por: Barone, Mariarita, et al.
Publicado: (2014)

Radiolabelled peptides for oncological diagnosis
por: Laverman, Peter, et al.
Publicado: (2012)

Targeting telomerase with radiolabeled inhibitors
por: Waghorn, Philip A., et al.
Publicado: (2017)

Radiolabeled Peptides and Antibodies in Medicine
por: Kręcisz, Paweł, et al.
Publicado: (2020)

Radiolabeling of Nanomaterials: Advantages and Challenges
por: Dai, Wanqin, et al.
Publicado: (2021)

Alternative polyadenylation of cyclooxygenase-2
por: Hall-Pogar, Tyra, et al.
Publicado: (2005)

Cyclooxygenase 2 expression in pterygium
por: Chiang, Chun-Chi, et al.
Publicado: (2007)

Significance of Cyclooxygenase-2 in Oncogenesis
por: Szweda, Marta, et al.
Publicado: (2019)

Radioligand therapies in cancer: mapping the educational landscape in Europe
por: Bugani, Valentina, et al.
Publicado: (2023)

Bis[2-(pyrimidin-2-ylamino)pyrimidinium] hexamolybdate
por: Yeh, Chun-Wei, et al.
Publicado: (2007)

Synthesis and (11)C-Radiolabelling of 2-Carboranyl Benzothiazoles
por: Gona, Kiran B., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_r4lr7tj09dsk0m05t9fjhve0fb