Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Thiouracil Derivatives as Potential Antithyroid Agents

Hyperthyroidism is the result of uncontrolled overproduction of the thyroid hormones. One of the mostly used antithyroid agents is 6-n-propyl-2-thiouracil (PTU). The previously solved X-ray crystal structure of the PTU bound to mammalian lactoperoxidase (LPO) reveals that the LPO-PTU binding site is...

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Detalles Bibliográficos
Autores principales: Awad, Samir M., Zohny, Yasser M., Ali, Sahar A., Mahgoub, Shahenda, Said, Ahmed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278332/
https://www.ncbi.nlm.nih.gov/pubmed/30413058
http://dx.doi.org/10.3390/molecules23112913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278332/
https://www.ncbi.nlm.nih.gov/pubmed/30413058
http://dx.doi.org/10.3390/molecules23112913

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