[O-methyl-(11)C]N-(4-(4-(3-Chloro-2-methoxyphenyl)-piperazin-1-yl)butyl)-1H-indole-2-carboxamide ([(11)C]BAK4-51) Is an Efflux Transporter Substrate and Ineffective for PET Imaging of Brain D(3) Receptors in Rodents and Monkey

Selective high-affinity antagonists for the dopamine D(3) receptor (D(3)R) are sought for treating substance use disorders. Positron emission tomography (PET) with an effective D(3)R radioligand could be a useful tool for the development of such therapeutics by elucidating pharmacological specificit...

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Detalles Bibliográficos
Autores principales: Liow, Jeih-San, Morse, Cheryl L., Lu, Shuiyu, Frankland, Michael, Tye, George L., Zoghbi, Sami S., Gladding, Robert L., Shaik, Anver B., Innis, Robert B., Newman, Amy H., Pike, Victor W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278341/
https://www.ncbi.nlm.nih.gov/pubmed/30360553
http://dx.doi.org/10.3390/molecules23112737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278341/
https://www.ncbi.nlm.nih.gov/pubmed/30360553
http://dx.doi.org/10.3390/molecules23112737

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