Dynamics-Derived Insights into Complex Formation between the CXCL8 Monomer and CXCR1 N-Terminal Domain: An NMR Study

Interleukin-8 (CXCL8), a potent neutrophil-activating chemokine, exerts its function by activating the CXCR1 receptor that belongs to class A G protein-coupled receptors (GPCRs). Receptor activation involves interactions between the CXCL8 N-terminal loop and CXCR1 N-terminal domain (N-domain) residu...

Descripción completa

Detalles Bibliográficos
Autores principales: Joseph, Prem Raj B., Spyracopoulos, Leo, Rajarathnam, Krishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278376/
https://www.ncbi.nlm.nih.gov/pubmed/30384436
http://dx.doi.org/10.3390/molecules23112825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278376/
https://www.ncbi.nlm.nih.gov/pubmed/30384436
http://dx.doi.org/10.3390/molecules23112825

Ejemplares similares