QSAR and Molecular Docking Studies of the Inhibitory Activity of Novel Heterocyclic GABA Analogues over GABA-AT

We have previously reported the synthesis, in vitro and in silico activities of new GABA analogues as inhibitors of the GABA-AT enzyme from Pseudomonas fluorescens, where the nitrogen atom at the γ-position is embedded in heterocyclic scaffolds. With the goal of finding more potent inhibitors, we no...

Descripción completa

Detalles Bibliográficos
Autores principales: Rodríguez-Lozada, Josué, Tovar-Gudiño, Erika, Guevara-Salazar, Juan Alberto, Razo-Hernández, Rodrigo Said, Santiago, Ángel, Pastor, Nina, Fernández-Zertuche, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278377/
https://www.ncbi.nlm.nih.gov/pubmed/30445747
http://dx.doi.org/10.3390/molecules23112984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278377/
https://www.ncbi.nlm.nih.gov/pubmed/30445747
http://dx.doi.org/10.3390/molecules23112984

Ejemplares similares