Computer-Aided Discovery of Small Molecule Inhibitors of Transcriptional Activity of TLX (NR2E1) Nuclear Receptor

Orphan nuclear receptor TLX (NR2E1) plays a critical role in the regulation of neural stem cells (NSC) as well as in the development of NSC-derived brain tumors. In the last years, new data have emerged implicating TLX in prostate and breast cancer. Therefore, inhibitors of TLX transcriptional activ...

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Detalles Bibliográficos
Autores principales: Dueva, Evgenia, Singh, Kriti, Kalyta, Anastasia, LeBlanc, Eric, Rennie, Paul S., Cherkasov, Artem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278398/
https://www.ncbi.nlm.nih.gov/pubmed/30441799
http://dx.doi.org/10.3390/molecules23112967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278398/
https://www.ncbi.nlm.nih.gov/pubmed/30441799
http://dx.doi.org/10.3390/molecules23112967

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