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Towards a Stochastic Paradigm: From Fuzzy Ensembles to Cellular Functions

The deterministic sequence → structure → function relationship is not applicable to describe how proteins dynamically adapt to different cellular conditions. A stochastic model is required to capture functional promiscuity, redundant sequence motifs, dynamic interactions, or conformational heterogen...

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Detalles Bibliográficos
Autor principal: Fuxreiter, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278454/
https://www.ncbi.nlm.nih.gov/pubmed/30453632
http://dx.doi.org/10.3390/molecules23113008