Imidazo[1,2-a]quinoxalines Derivatives Grafted with Amino Acids: Synthesis and Evaluation on A375 Melanoma Cells

Imiqualines (imidazoquinoxaline derivatives) are anticancer compounds with high cytotoxic activities on melanoma cell lines. The first generation of imiqualines, with two lead compounds (EAPB0203 and EAPB0503), shows remarkable in vitro (IC(50) = 1 570 nM and IC(50) = 200 nM, respectively, on the A3...

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Detalles Bibliográficos
Autores principales: Chouchou, Adrien, Patinote, Cindy, Cuq, Pierre, Bonnet, Pierre-Antoine, Deleuze-Masquéfa, Carine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278480/
https://www.ncbi.nlm.nih.gov/pubmed/30445763
http://dx.doi.org/10.3390/molecules23112987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278480/
https://www.ncbi.nlm.nih.gov/pubmed/30445763
http://dx.doi.org/10.3390/molecules23112987

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