Analytical Profiling of Proanthocyanidins from Acacia mearnsii Bark and In Vitro Assessment of Antioxidant and Antidiabetic Potential

The proanthocyanidins from ethanol extracts (80%, v/v) of Acacia mearnsii (A. mearnsii) bark on chemical-based and cellular antioxidant activity assays as well as carbolytic enzyme inhibitory activities were studied. About 77% of oligomeric proanthocyanidins in ethanol extracts of A. mearnsii bark w...

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Autores principales: Chen, Xiao, Xiong, Jia, Huang, Shenlin, Li, Xun, Zhang, Yu, Zhang, Liping, Wang, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278516/
https://www.ncbi.nlm.nih.gov/pubmed/30404154
http://dx.doi.org/10.3390/molecules23112891
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author Chen, Xiao
Xiong, Jia
Huang, Shenlin
Li, Xun
Zhang, Yu
Zhang, Liping
Wang, Fei
author_facet Chen, Xiao
Xiong, Jia
Huang, Shenlin
Li, Xun
Zhang, Yu
Zhang, Liping
Wang, Fei
author_sort Chen, Xiao
collection PubMed
description The proanthocyanidins from ethanol extracts (80%, v/v) of Acacia mearnsii (A. mearnsii) bark on chemical-based and cellular antioxidant activity assays as well as carbolytic enzyme inhibitory activities were studied. About 77% of oligomeric proanthocyanidins in ethanol extracts of A. mearnsii bark were found by using normal-phase HPLC. In addition, HPLC-ESI-TOF/MS and MALDI-TOF/TOF MS analyses indicated that proanthocyanidins from A. mearnsii bark exhibited with a degree of polymerization ranging from 1 to 11. These results of combined antioxidant activity assays, as well as carbolytic enzyme inhibitory activities of proanthocyanidins from A. mearnsii bark, indicated an encouraging antioxidant capacity for the high polyphenol content and a potential for use as alternative drugs for lowering the glycemic response.
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spelling pubmed-62785162018-12-13 Analytical Profiling of Proanthocyanidins from Acacia mearnsii Bark and In Vitro Assessment of Antioxidant and Antidiabetic Potential Chen, Xiao Xiong, Jia Huang, Shenlin Li, Xun Zhang, Yu Zhang, Liping Wang, Fei Molecules Article The proanthocyanidins from ethanol extracts (80%, v/v) of Acacia mearnsii (A. mearnsii) bark on chemical-based and cellular antioxidant activity assays as well as carbolytic enzyme inhibitory activities were studied. About 77% of oligomeric proanthocyanidins in ethanol extracts of A. mearnsii bark were found by using normal-phase HPLC. In addition, HPLC-ESI-TOF/MS and MALDI-TOF/TOF MS analyses indicated that proanthocyanidins from A. mearnsii bark exhibited with a degree of polymerization ranging from 1 to 11. These results of combined antioxidant activity assays, as well as carbolytic enzyme inhibitory activities of proanthocyanidins from A. mearnsii bark, indicated an encouraging antioxidant capacity for the high polyphenol content and a potential for use as alternative drugs for lowering the glycemic response. MDPI 2018-11-06 /pmc/articles/PMC6278516/ /pubmed/30404154 http://dx.doi.org/10.3390/molecules23112891 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Xiao
Xiong, Jia
Huang, Shenlin
Li, Xun
Zhang, Yu
Zhang, Liping
Wang, Fei
Analytical Profiling of Proanthocyanidins from Acacia mearnsii Bark and In Vitro Assessment of Antioxidant and Antidiabetic Potential
title Analytical Profiling of Proanthocyanidins from Acacia mearnsii Bark and In Vitro Assessment of Antioxidant and Antidiabetic Potential
title_full Analytical Profiling of Proanthocyanidins from Acacia mearnsii Bark and In Vitro Assessment of Antioxidant and Antidiabetic Potential
title_fullStr Analytical Profiling of Proanthocyanidins from Acacia mearnsii Bark and In Vitro Assessment of Antioxidant and Antidiabetic Potential
title_full_unstemmed Analytical Profiling of Proanthocyanidins from Acacia mearnsii Bark and In Vitro Assessment of Antioxidant and Antidiabetic Potential
title_short Analytical Profiling of Proanthocyanidins from Acacia mearnsii Bark and In Vitro Assessment of Antioxidant and Antidiabetic Potential
title_sort analytical profiling of proanthocyanidins from acacia mearnsii bark and in vitro assessment of antioxidant and antidiabetic potential
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278516/
https://www.ncbi.nlm.nih.gov/pubmed/30404154
http://dx.doi.org/10.3390/molecules23112891
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