Cargando…

Panax notoginseng Saponins Protect Cerebral Microvascular Endothelial Cells against Oxygen-Glucose Deprivation/Reperfusion-Induced Barrier Dysfunction via Activation of PI3K/Akt/Nrf2 Antioxidant Signaling Pathway

Oxidative stress plays a critical role in cerebral ischemia/reperfusion (I/R)-induced blood-brain barrier (BBB) disruption. Panax notoginseng saponins (PNS) possess efficient antioxidant activity and have been used in the treatment of cerebral ischemic stroke in China. In this study, we determined t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Shaonan, Wu, Yali, Zhao, Bo, Hu, Haiyan, Zhu, Baochen, Sun, Zongxi, Li, Pengyue, Du, Shouying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278530/ https://www.ncbi.nlm.nih.gov/pubmed/30373188 http://dx.doi.org/10.3390/molecules23112781

Ejemplares similares

Effects of Panax Notoginseng Saponins on Esterases Responsible for Aspirin Hydrolysis In Vitro
por: Sun, Zongxi, et al.
Publicado: (2018)

Inhibitory Influence of Panax notoginseng Saponins on Aspirin Hydrolysis in Human Intestinal Caco-2 Cells
por: Sun, Zongxi, et al.
Publicado: (2018)

Comparative Analysis of Compatibility Influence on Invigorating Blood Circulation for Combined Use of Panax Notoginseng Saponins and Aspirin Using Metabolomics Approach
por: Sun, Zongxi, et al.
Publicado: (2021)

Saponin accumulation in the seedling root of Panax notoginseng
por: Wang, Dong, et al.
Publicado: (2011)

New dammarane-type triterpenoid saponins from Panax notoginseng saponins
por: Li, Qian, et al.
Publicado: (2020)

Pustular drug eruption due to Panax notoginseng saponins
por: Yin, ZhiQiang, et al.
Publicado: (2014)

Stereoisomers of Saponins in Panax notoginseng (Sanqi): A Review
por: Peng, Ming, et al.
Publicado: (2018)

Chemical transformation and target preparation of saponins in stems and leaves of Panax notoginseng
por: Wang, Ru-Feng, et al.
Publicado: (2018)

In Vitro Evaluation of the Neuroprotective Effect of Panax notoginseng Saponins by Activating the EGFR/PI3K/AKT Pathway
por: Wu, Shuang, et al.
Publicado: (2020)

High-throughput transcriptional profiling of perturbations by Panax ginseng saponins and Panax notoginseng saponins using TCM-seq
por: Cheng, Junyun, et al.
Publicado: (2023)

Pharmacokinetics study of bio-adhesive tablet of Panax notoginseng saponins
por: Feng, Hanzhou, et al.
Publicado: (2011)

Dammarane-type saponins from steamed leaves of Panax Notoginseng
por: Liu, Qing, et al.
Publicado: (2011)

Dammarane-type Triterpene Saponins from the Flowers of Panax notoginseng
por: Wang, Jing-Rong, et al.
Publicado: (2009)

Metabolomes and transcriptomes revealed the saponin distribution in root tissues of Panax quinquefolius and Panax notoginseng
por: Wei, Guangfei, et al.
Publicado: (2020)

Effect of Panax notoginseng Saponins on Focal Cerebral Ischemia-Reperfusion in Rat Models: A Meta-Analysis
por: Sun, Tao, et al.
Publicado: (2021)

Integrated metabolomic and transcriptomic analyses revealed the distribution of saponins in Panax notoginseng
por: Wei, Guangfei, et al.
Publicado: (2018)

Structure and Location Studies on Key Enzymes in Saponins Biosynthesis of Panax notoginseng
por: Xia, Pengguo, et al.
Publicado: (2019)

Pharmacological Effect of Panax notoginseng Saponins on Cerebral Ischemia in Animal Models
por: Dong, Chao, et al.
Publicado: (2022)

Panax notoginseng Saponins for Treating Coronary Artery Disease: A Functional and Mechanistic Overview
por: Duan, Lian, et al.
Publicado: (2017)

Effect of the combination of astragaloside IV and Panax notoginseng saponins on pyroptosis and necroptosis in rat models of cerebral ischemia-reperfusion
por: Tang, Biao, et al.
Publicado: (2021)

Panax Notoginseng Saponins Prevent Bone Loss by Promoting Angiogenesis in an Osteoporotic Mouse Model
por: Hu, Hao, et al.
Publicado: (2020)

Cardioprotective Effect of Stem-Leaf Saponins From Panax notoginseng on Mice With Sleep Deprivation by Inhibiting Abnormal Autophagy Through PI3K/Akt/mTOR Pathway
por: Cao, Yin, et al.
Publicado: (2021)

ATP-Sensitive Potassium Channels Mediate the Cardioprotective Effect of Panax notoginseng Saponins against Myocardial Ischaemia–Reperfusion Injury and Inflammatory Reaction
por: Ning, Ke, et al.
Publicado: (2020)

Anaphylactic Rare Saponins Separated from Panax notoginseng Saponin and a Proteomic Approach to Their Anaphylactic Mechanism
por: Hao, Feiran, et al.
Publicado: (2022)

Effects of total saponins of Panax notoginseng on immature neuroblasts in the adult olfactory bulb following global cerebral ischemia/reperfusion
por: He, Xu, et al.
Publicado: (2015)

Quantitative Comparison and Metabolite Profiling of Saponins in Different Parts of the Root of Panax notoginseng
por: Wang, Jing-Rong, et al.
Publicado: (2014)

Effect of Panax notoginseng Saponins and Major Anti-Obesity Components on Weight Loss
por: Zhang, Xuelian, et al.
Publicado: (2021)

Panax notoginseng saponins and their applications in nervous system disorders: a narrative review
por: Qu, Jing, et al.
Publicado: (2020)

Panax notoginseng saponins prevent senescence and inhibit apoptosis by regulating the PI3K-AKT-mTOR pathway in osteoarthritic chondrocytes
por: Zhang, Yubiao, et al.
Publicado: (2021)

Panax notoginseng saponins prevent senescence and inhibit apoptosis by regulating the PI3K-AKT-mTOR pathway in osteoarthritic chondrocytes
por: Zhang, Yubiao, et al.
Publicado: (2022)

Corrigendum: Cardioprotective Effect of Stem-Leaf Saponins From Panax notoginseng on Mice With Sleep Deprivation by Inhibiting Abnormal Autophagy Through PI3K/Akt/mTOR Pathway
por: Cao, Yin, et al.
Publicado: (2022)

Panax notoginseng saponins radiosensitize colorectal cancer cells by regulating the SNHG6/miR-137 axis
por: Xu, Caihui, et al.
Publicado: (2019)

Panax notoginseng saponin attenuates hypoxia/reoxygenation-induced oxidative stress in cortical neurons★
por: Yan, Chen, et al.
Publicado: (2012)

Panax notoginseng saponins alleviate osteoporosis and joint destruction in rabbits with antigen-induced arthritis
por: Wei, Chen Chao, et al.
Publicado: (2021)

A Network Pharmacology Approach for Exploring the Mechanisms of Panax notoginseng Saponins in Ischaemic Stroke
por: Wang, Cong, et al.
Publicado: (2021)

Physicochemical, Digestive, and Sensory Properties of Panax Notoginseng Saponins Encapsulated by Polymerized Whey Protein
por: Zhou, Zengjia, et al.
Publicado: (2021)

Gut-liver axis modulation of Panax notoginseng saponins in nonalcoholic fatty liver disease
por: Xu, Yu, et al.
Publicado: (2021)

Panax notoginseng Saponin Protects Against Diabetic Cardiomyopathy Through Lipid Metabolism Modulation
por: Zhang, Chenyang, et al.
Publicado: (2022)

Suitable soil moisture contents for water use efficiency and saponins accumulation in Panax notoginseng
por: Zheng, Yu-jie, et al.
Publicado: (2021)

High nitrogen inhibits biomass and saponins accumulation in a medicinal plant Panax notoginseng
por: Cun, Zhu, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_bkt8krth5j76ira4s14tes5j17