Cargando…

Pseudoginsengenin DQ Exhibits Therapeutic Effects in Cisplatin-Induced Acute Kidney Injury via Sirt1/NF-κB and Caspase Signaling Pathway without Compromising Its Antitumor Activity in Mice

In this study, the protective effects of pseudoginsengenin DQ (PDQ) on cisplatin (CDDP)-induced nephrotoxicity were assessed, with a primary investigation into the mechanisms involved. Our results showed that pretreatment with PDQ remarkably restored levels of blood urea nitrogen (BUN) and creatinin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qi, Zeng, Li, Zhuo, Li, Wei, Liu, Yunhe, Wang, Cuizhu, Lin, Hongqiang, Liu, Jinping, Li, Pingya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278544/ https://www.ncbi.nlm.nih.gov/pubmed/30469321 http://dx.doi.org/10.3390/molecules23113038

Ejemplares similares

Pharmacokinetic and Metabolism Studies of 12-Riboside-Pseudoginsengenin DQ by UPLC-MS/MS and UPLC-QTOF-MS(E)
por: Wang, Zhenzhou, et al.
Publicado: (2018)

Pseudo-ginsengenin DQ ameliorated aconitine-induced arrhythmias by influencing Ca(2+) and K(+) currents in ventricular myocytes
por: Jin, Lifang, et al.
Publicado: (2020)

Pseudoginsengenin DQ exerts antitumour activity against hypopharyngeal cancer cells by targeting the HIF-1α-GLUT1 pathway
por: Wang, Sanchun, et al.
Publicado: (2021)

Discovery of the Potential Biomarkers for Discrimination between Hedyotis diffusa and Hedyotis corymbosa by UPLC-QTOF/MS Metabolome Analysis
por: Wang, Yaru, et al.
Publicado: (2018)

UPLC-QTOF/MS-Based Nontargeted Metabolomic Analysis of Mountain- and Garden-Cultivated Ginseng of Different Ages in Northeast China
por: Zhu, Hailin, et al.
Publicado: (2018)

Effects of Platycodins Folium on Depression in Mice Based on a UPLC-Q/TOF-MS Serum Assay and Hippocampus Metabolomics
por: Wang, Cuizhu, et al.
Publicado: (2019)

Four Novel Dammarane-Type Triterpenoids from Pearl Knots of Panax ginseng Meyer cv. Silvatica
por: Qi, Zeng, et al.
Publicado: (2019)

Comprehensive metabolomics analysis based on UPLC-Q/TOF-MS(E) and the anti-COPD effect of different parts of Celastrus orbiculatus Thunb.
por: Yang, Na, et al.
Publicado: (2020)

Pharmacokinetic and Metabolism Studies of Curculigoside C by UPLC-MS/MS and UPLC-QTOF-MS
por: Wu, Di, et al.
Publicado: (2018)

Integrated Metabolomics and Network Pharmacology to Decipher the Latent Mechanisms of Protopanaxatriol against Acetic Acid-Induced Gastric Ulcer
por: Wang, Cuizhu, et al.
Publicado: (2022)

Neuroprotective Effects and Metabolomics Study of Protopanaxatriol (PPT) on Cerebral Ischemia/Reperfusion Injury In Vitro and In Vivo
por: Wu, Fulin, et al.
Publicado: (2023)

Study on the Comprehensive Phytochemicals and the Anti-Ulcerative Colitis Effect of Saussurea pulchella
por: Liu, Yunhe, et al.
Publicado: (2023)

Non-Targeted Metabolomic Analysis of Methanolic Extracts of Wild-Simulated and Field-Grown American Ginseng
por: Lin, Hongqiang, et al.
Publicado: (2019)

Protective Effects of Protopanaxatriol Saponins on Ulcerative Colitis in Mouse Based on UPLC-Q/TOF-MS Serum and Colon Metabolomics
por: Wu, Fulin, et al.
Publicado: (2022)

Evaluation of the gastroprotective effects of 20 (S)-ginsenoside Rg3 on gastric ulcer models in mice
por: Zhang, Kai, et al.
Publicado: (2019)

Protective Effect of Ethyl Rosmarinate against Ulcerative Colitis in Mice Based on Untargeted Metabolomics
por: Zhou, Baisong, et al.
Publicado: (2022)

Comprehensive Metabolomics Analysis of Xueshuan Xinmaining Tablet in Blood Stasis Model Rats Using UPLC-Q/TOF-MS
por: Tan, Jing, et al.
Publicado: (2018)

Nontargeted Metabolomic Analysis of Four Different Parts of Platycodon grandiflorum Grown in Northeast China
por: Wang, Cuizhu, et al.
Publicado: (2017)

Exploitation of necroptosis for treatment of caspase-compromised cancers
por: Cho, Young Sik, et al.
Publicado: (2017)

Daphnetin Attenuated Cisplatin-Induced Acute Nephrotoxicity With Enhancing Antitumor Activity of Cisplatin by Upregulating SIRT1/SIRT6-Nrf2 Pathway
por: Fan, Xiaoye, et al.
Publicado: (2020)

Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics
por: Wang, Cuizhu, et al.
Publicado: (2020)

DQ2, DQ7 and DQ8 Distribution and Clinical Manifestations in Celiac Cases and Their First-Degree Relatives
por: Araya, Magdalena, et al.
Publicado: (2015)

The incidence of HLA-DQ2/DQ8 in Turkish children with celiac disease and a comparison of the geographical distribution of HLA-DQ
por: Basturk, Ahmet, et al.
Publicado: (2017)

HLA-DQ2 and -DQ8 genotype frequency in Syrian celiac disease children: HLA-DQ relative risks evaluation
por: Murad, Hossam, et al.
Publicado: (2018)

Enhanced Extracellular Transfer of HLA-DQ Activates CD3(+) Lymphocytes towards Compromised Treg Induction in Celiac Disease
por: Hudec, Michael, et al.
Publicado: (2022)

Comparative Analysis of Chemical Constituents of Moringa oleifera Leaves from China and India by Ultra-Performance Liquid Chromatography Coupled with Quadrupole-Time-Of-Flight Mass Spectrometry
por: Lin, Hongqiang, et al.
Publicado: (2019)

Human Amniotic Epithelial Cells and Their Derived Exosomes Protect Against Cisplatin-Induced Acute Kidney Injury Without Compromising Its Antitumor Activity in Mice
por: Kang, Xin, et al.
Publicado: (2022)

The deacetylation of Foxk2 by Sirt1 reduces chemosensitivity to cisplatin
por: Wang, Xi‐wen, et al.
Publicado: (2021)

A cisplatin conjugate with tumor cell specificity exhibits antitumor effects in renal cancer models
por: Mrdenovic, Stefan, et al.
Publicado: (2023)

A dark quencher genetically encodable voltage indicator (dqGEVI) exhibits high fidelity and speed
por: Alich, Therese C., et al.
Publicado: (2021)

Inhibitory Effect of Triterpenoids from Panax ginseng on Coagulation Factor X
por: Xiong, Lingxin, et al.
Publicado: (2017)

The Antitumor Potential of Extract of the Oak Bracket Medicinal Mushroom Inonotus baumii in SMMC-7721 Tumor Cells
por: Yang, Yue, et al.
Publicado: (2019)

THE PREVALENCE OF HLA DQ2 AND DQ8 IN PATIENTS WITH CELIAC DISEASE, IN FAMILY AND IN GENERAL POPULATION
por: CECILIO, Lucila Arantes, et al.
Publicado: (2015)

The likelihood ratio and frequency of DQ2/DQ8 haplotypes in Iranian patients with celiac disease
por: Khosravi, Asghar, et al.
Publicado: (2016)

Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease
por: Almeida, Lucas Malta, et al.
Publicado: (2016)

Prevalence of haplotype DQ2/DQ8 and celiac disease in children with type 1 diabetes
por: Zubkiewicz-Kucharska, Agnieszka, et al.
Publicado: (2022)

Meta-Analysis and Systematic Review of HLA DQ2/DQ8 in Adults with Celiac Disease
por: Aboulaghras, Sara, et al.
Publicado: (2023)

Synthesis and Anti-Hepatocarcinoma Effect of Amino Acid Derivatives of Pyxinol and Ocotillol
por: Zhang, Ying, et al.
Publicado: (2021)

Polymorphic DQ alpha and DQ beta interactions dictate HLA class II determinants of allo-recognition
Publicado: (1990)

HLA-DQ-Specific Recombinant Human Monoclonal Antibodies Allow for In-Depth Analysis of HLA-DQ Epitopes
por: Bezstarosti, Suzanne, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qnufc1c8gogrgmb0vgbopo21ps