Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia-inducible factor 1α-mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation

Medulloblastomas are among the most frequently diagnosed pediatric solid tumors, and drug resistance remains as the principal cause of treatment failure. Hypoxia and the subsequent activation of hypoxia-inducible factor 1α (HIF-1α) are considered key factors in modulating drug antitumor effectivenes...

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Detalles Bibliográficos
Autores principales: Valencia-Cervantes, Jesús, Huerta-Yepez, Sara, Aquino-Jarquín, Guillermo, Rodríguez-Enríquez, Sara, Martínez-Fong, Daniel, Arias-Montaño, José-Antonio, Dávila-Borja, Víctor Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278548/
https://www.ncbi.nlm.nih.gov/pubmed/30320358
http://dx.doi.org/10.3892/or.2018.6790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278548/
https://www.ncbi.nlm.nih.gov/pubmed/30320358
http://dx.doi.org/10.3892/or.2018.6790

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