Multi-Gram Synthesis of Enantiopure 1,5-Disubstituted Tetrazoles Via Ugi-Azide 3-Component Reaction

Tetrazoles have been widely studied for their biological properties. An efficient route for large-scale synthesis of 1,5-disubstituted tetrazoles (1,5-DTs) is presented. The strategy exploits a reductive approach to synthetize a cyclic chiral imine substrate which is then converted into the target p...

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Detalles Bibliográficos
Autores principales: Capurro, Pietro, Moni, Lisa, Galatini, Andrea, Mang, Christian, Basso, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278549/
https://www.ncbi.nlm.nih.gov/pubmed/30366358
http://dx.doi.org/10.3390/molecules23112758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278549/
https://www.ncbi.nlm.nih.gov/pubmed/30366358
http://dx.doi.org/10.3390/molecules23112758

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