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Enhanced Stability of DNA Oligonucleotides with Partially Zwitterionic Backbone Structures in Biological Media †
Deficient stability towards nuclease-mediated degradation is one of the most relevant tasks in the development of oligonucleotide-derived biomedical agents. This hurdle can be overcome through modifications to the native oligonucleotide backbone structure, with the goal of simultaneously retaining t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278555/ https://www.ncbi.nlm.nih.gov/pubmed/30423832 http://dx.doi.org/10.3390/molecules23112941 |