Lysyl Hydroxylase Inhibition by Minoxidil Blocks Collagen Deposition and Prevents Pulmonary Fibrosis via TGF-β(1)/Smad3 Signaling Pathway

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a deadly disease characterized by excessive collagen in the extracellular matrix (ECM) of the lungs. Collagen is the primary protein component of the ECM. However, the exact mechanisms underlying the formation and deposition of collagen in the ECM u...

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Detalles Bibliográficos
Autores principales: Shao, Songjun, Zhang, Xiangning, Duan, Lingdi, Fang, Haiyan, Rao, Shanshan, Liu, Weijia, Guo, Bing, Zhang, Xiangyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278642/
https://www.ncbi.nlm.nih.gov/pubmed/30481795
http://dx.doi.org/10.12659/MSM.910761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278642/
https://www.ncbi.nlm.nih.gov/pubmed/30481795
http://dx.doi.org/10.12659/MSM.910761

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