Overcoming the Undesirable CRISPR-Cas9 Expression in Gene Correction

The CRISPR-Cas9 system is attractive for gene therapy, as it allows for permanent genetic correction. However, as a new technology, Cas9 gene editing in clinical applications faces major challenges, such as safe delivery and gene targeting efficiency. Cas9 is a foreign protein to recipient cells; th...

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Detalles Bibliográficos
Autores principales: Xia, Emily, Duan, Rongqi, Shi, Fushan, Seigel, Kyle E., Grasemann, Hartmut, Hu, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278715/
https://www.ncbi.nlm.nih.gov/pubmed/30513454
http://dx.doi.org/10.1016/j.omtn.2018.10.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278715/
https://www.ncbi.nlm.nih.gov/pubmed/30513454
http://dx.doi.org/10.1016/j.omtn.2018.10.015

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