Shifting Retroviral Vector Integrations Away from Transcriptional Start Sites via DNA-Binding Protein Domain Insertion into Integrase

The unique ability of retroviruses to integrate genes into host genomes is of great value for long-term expression in gene therapy, but only when integrations occur at safe genomic sites. To reap the benefit of using retroviruses without severe detrimental effects, we developed several murine leukem...

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Detalles Bibliográficos
Autores principales: Nam, Jung-soo, Lee, Ji-eun, Lee, Kwang-hee, Yang, Yeji, Kim, Soo-hyun, Bae, Gyu-un, Noh, Hohsuk, Lim, Kwang-il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278723/
https://www.ncbi.nlm.nih.gov/pubmed/30534579
http://dx.doi.org/10.1016/j.omtm.2018.11.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278723/
https://www.ncbi.nlm.nih.gov/pubmed/30534579
http://dx.doi.org/10.1016/j.omtm.2018.11.001

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