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Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
Visualization of amyloid-β (Aβ) pathology with PET has become an important tool for making a specific clinical diagnosis of Alzheimer disease (AD). However, the available amyloid PET radioligands, such as (11)C-Pittsburgh compound B, reflect levels of insoluble Aβ plaques but do not capture soluble...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Society of Nuclear Medicine
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278900/ https://www.ncbi.nlm.nih.gov/pubmed/29853653 http://dx.doi.org/10.2967/jnumed.118.213140 |