Reduced structural flexibility for an exonuclease deficient DNA polymerase III mutant†

DNA synthesis, carried out by DNA polymerases, requires balancing speed and accuracy for faithful replication of the genome. High fidelity DNA polymerases contain a 3′–5′ exonuclease domain that can remove misincorporated nucleotides on the 3′ end of the primer strand, a process called proofreading....

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Detalles Bibliográficos
Autores principales: Gahlon, Hailey L., Walker, Alice R., Cisneros, G. Andre´s, Lamers, Meindert H., Rueda, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278910/
https://www.ncbi.nlm.nih.gov/pubmed/30345999
http://dx.doi.org/10.1039/c8cp04112a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278910/
https://www.ncbi.nlm.nih.gov/pubmed/30345999
http://dx.doi.org/10.1039/c8cp04112a

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