N-linked glycosylation modulates the immunogenicity of recombinant human factor VIII in hemophilia A mice

Immune responses to factor VIII remain the greatest complication in the treatment of severe hemophilia A. Recent epidemiological evidence has highlighted that recombinant factor VIII produced in baby hamster kidney cells is more immunogenic than factor VIII produced in Chinese hamster ovary cells. G...

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Detalles Bibliográficos
Autores principales: Lai, Jesse D., Swystun, Laura L., Cartier, Dominique, Nesbitt, Kate, Zhang, Cunjie, Hough, Christine, Dennis, James W., Lillicrap, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278987/
https://www.ncbi.nlm.nih.gov/pubmed/30002126
http://dx.doi.org/10.3324/haematol.2018.188219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278987/
https://www.ncbi.nlm.nih.gov/pubmed/30002126
http://dx.doi.org/10.3324/haematol.2018.188219

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