A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold

A key step in nutrient sensing is the activation of the master growth regulator, mTORC1 kinase, on the surface of lysosomes. Nutrients enable mTORC1 scaffolding by a complex composed of the Rag GTPases (Rags) and Ragulator, but the underlying mechanism of mTORC1 capture is poorly understood. Combini...

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Detalles Bibliográficos
Autores principales: Lawrence, Rosalie E., Cho, Kelvin F., Rappold, Ronja, Thrun, Anna, Tofaute, Marie, Kim, Do Jin, Moldavski, Ofer, Hurley, James H., Zoncu, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279252/
https://www.ncbi.nlm.nih.gov/pubmed/30061680
http://dx.doi.org/10.1038/s41556-018-0148-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279252/
https://www.ncbi.nlm.nih.gov/pubmed/30061680
http://dx.doi.org/10.1038/s41556-018-0148-6

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