CD27 stimulation unveils the efficacy of linked class I/II peptide vaccines in poorly immunogenic tumors by orchestrating a coordinated CD4/CD8 T cell response

Despite their promise, tumor-specific peptide vaccines have limited efficacy. CD27 is a costimulatory molecule expressed on CD4(+) and CD8(+) T cells that is important in immune activation. Here we determine if a novel CD27 agonist antibody (αhCD27) can enhance the antitumor T cell response and effi...

Descripción completa

Detalles Bibliográficos
Autores principales: Riccione, Katherine A., He, Li-Zhen, Fecci, Peter E., Norberg, Pamela K., Suryadevara, Carter M., Swartz, Adam, Healy, Patrick, Reap, Elizabeth, Keler, Tibor, Li, Qi-Jing, Congdon, Kendra L., Sanchez-Perez, Luis, Sampson, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279317/
https://www.ncbi.nlm.nih.gov/pubmed/30524899
http://dx.doi.org/10.1080/2162402X.2018.1502904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279317/
https://www.ncbi.nlm.nih.gov/pubmed/30524899
http://dx.doi.org/10.1080/2162402X.2018.1502904

Ejemplares similares