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CD27 stimulation unveils the efficacy of linked class I/II peptide vaccines in poorly immunogenic tumors by orchestrating a coordinated CD4/CD8 T cell response

Despite their promise, tumor-specific peptide vaccines have limited efficacy. CD27 is a costimulatory molecule expressed on CD4(+) and CD8(+) T cells that is important in immune activation. Here we determine if a novel CD27 agonist antibody (αhCD27) can enhance the antitumor T cell response and effi...

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Detalles Bibliográficos
Autores principales:	Riccione, Katherine A., He, Li-Zhen, Fecci, Peter E., Norberg, Pamela K., Suryadevara, Carter M., Swartz, Adam, Healy, Patrick, Reap, Elizabeth, Keler, Tibor, Li, Qi-Jing, Congdon, Kendra L., Sanchez-Perez, Luis, Sampson, John H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279317/ https://www.ncbi.nlm.nih.gov/pubmed/30524899 http://dx.doi.org/10.1080/2162402X.2018.1502904

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