Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation

Tryptophan (Trp) metabolism is an important target in immuno-oncology as it represents a powerful immunosuppressive mechanism hijacked by tumors for protection against immune destruction. However, it remains unclear how tumor cells can proliferate while degrading the essential amino acid Trp. Trp is...

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Detalles Bibliográficos
Autores principales: Adam, Isabell, Dewi, Dyah L., Mooiweer, Joram, Sadik, Ahmed, Mohapatra, Soumya R., Berdel, Bianca, Keil, Melanie, Sonner, Jana K., Thedieck, Kathrin, Rose, Adam J., Platten, Michael, Heiland, Ines, Trump, Saskia, Opitz, Christiane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279332/
https://www.ncbi.nlm.nih.gov/pubmed/30524887
http://dx.doi.org/10.1080/2162402X.2018.1486353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279332/
https://www.ncbi.nlm.nih.gov/pubmed/30524887
http://dx.doi.org/10.1080/2162402X.2018.1486353

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