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GTP hydrolysis promotes disassembly of the atlastin crossover dimer during ER fusion

Membrane fusion of the ER is catalyzed when atlastin GTPases anchored in opposing membranes dimerize and undergo a crossed over conformational rearrangement that draws the bilayers together. Previous studies have suggested that GTP hydrolysis triggers crossover dimerization, thus directly driving fu...

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Detalles Bibliográficos
Autores principales: Winsor, James, Machi, Ursula, Han, Qixiu, Hackney, David D., Lee, Tina H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279388/
https://www.ncbi.nlm.nih.gov/pubmed/30249723
http://dx.doi.org/10.1083/jcb.201805039