HDAC stimulates gene expression through BRD4 availability in response to IFN and in interferonopathies

In contrast to the common role of histone deacetylases (HDACs) for gene repression, HDAC activity provides a required positive function for IFN-stimulated gene (ISG) expression. Here, we show that HDAC1/2 as components of the Sin3A complex are required for ISG transcriptional elongation but not for...

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Detalles Bibliográficos
Autores principales: Marié, Isabelle J., Chang, Hao-Ming, Levy, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279398/
https://www.ncbi.nlm.nih.gov/pubmed/30463877
http://dx.doi.org/10.1084/jem.20180520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279398/
https://www.ncbi.nlm.nih.gov/pubmed/30463877
http://dx.doi.org/10.1084/jem.20180520

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