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HDAC stimulates gene expression through BRD4 availability in response to IFN and in interferonopathies

In contrast to the common role of histone deacetylases (HDACs) for gene repression, HDAC activity provides a required positive function for IFN-stimulated gene (ISG) expression. Here, we show that HDAC1/2 as components of the Sin3A complex are required for ISG transcriptional elongation but not for...

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Detalles Bibliográficos
Autores principales:	Marié, Isabelle J., Chang, Hao-Ming, Levy, David E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279398/ https://www.ncbi.nlm.nih.gov/pubmed/30463877 http://dx.doi.org/10.1084/jem.20180520

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