Genetic models reveal origin, persistence and non-redundant functions of IL-17–producing γδ T cells

γδ T cells are highly conserved in jawed vertebrates, suggesting an essential role in the immune system. However, γδ T cell–deficient Tcrd(−/−) mice display surprisingly mild phenotypes. We hypothesized that the lack of γδ T cells in constitutive Tcrd(−/−) mice is functionally compensated by other l...

Descripción completa

Detalles Bibliográficos
Autores principales: Sandrock, Inga, Reinhardt, Annika, Ravens, Sarina, Binz, Christoph, Wilharm, Anneke, Martins, Joana, Oberdörfer, Linda, Tan, Likai, Lienenklaus, Stefan, Zhang, Baojun, Naumann, Ronald, Zhuang, Yuan, Krueger, Andreas, Förster, Reinhold, Prinz, Immo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279411/
https://www.ncbi.nlm.nih.gov/pubmed/30455268
http://dx.doi.org/10.1084/jem.20181439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279411/
https://www.ncbi.nlm.nih.gov/pubmed/30455268
http://dx.doi.org/10.1084/jem.20181439

Ejemplares similares