Dietary DHA amplifies LXA(4) circuits in tissues and lymph node PMN and is protective in immune-driven dry eye disease

Recently identified regulatory PMN control immune-driven dry eye disease (DED) in females by producing the arachidonic acid (ɷ−6)-derived specialized pro-resolving mediator (SPM), LXA(4), in lymph nodes. Dietary ɷ−3 docosahexaenoic acid (DHA) is protective in DED but mechanisms of action remain elus...

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Detalles Bibliográficos
Autores principales: Gao, Yuan, Su, John, Zhang, Yibing, Chan, Allison, Sin, Jun Hyung, Wu, Di, Min, Kyungi, Gronert, Karsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279588/
https://www.ncbi.nlm.nih.gov/pubmed/30104626
http://dx.doi.org/10.1038/s41385-018-0070-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279588/
https://www.ncbi.nlm.nih.gov/pubmed/30104626
http://dx.doi.org/10.1038/s41385-018-0070-z

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