A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer’s disease mouse model

We describe here the results from the testing of a small molecule first-in-class apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, A03, that increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic sirtuin 2 (SirT2) in vitro in ApoE4-transfected c...

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Detalles Bibliográficos
Autores principales: Campagna, Jesus, Spilman, Patricia, Jagodzinska, Barbara, Bai, Dongsheng, Hatami, Asa, Zhu, Chunni, Bilousova, Tina, Jun, Michael, Elias, Chris Jean, Pham, Johnny, Cole, Gregory, LaDu, Mary Jo, Jung, Michael E., Bredesen, Dale E., John, Varghese
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279743/
https://www.ncbi.nlm.nih.gov/pubmed/30514854
http://dx.doi.org/10.1038/s41598-018-35687-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279743/
https://www.ncbi.nlm.nih.gov/pubmed/30514854
http://dx.doi.org/10.1038/s41598-018-35687-8

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