Ranking noncanonical 5′ splice site usage by genome-wide RNA-seq analysis and splicing reporter assays

Most human pathogenic mutations in 5′ splice sites affect the canonical GT in positions +1 and +2, leading to noncanonical dinucleotides. On the other hand, noncanonical dinucleotides are observed under physiological conditions in ∼1% of all human 5′ss. It is therefore a challenging task to understa...

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Detalles Bibliográficos
Autores principales: Erkelenz, Steffen, Theiss, Stephan, Kaisers, Wolfgang, Ptok, Johannes, Walotka, Lara, Müller, Lisa, Hillebrand, Frank, Brillen, Anna-Lena, Sladek, Michael, Schaal, Heiner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280755/
https://www.ncbi.nlm.nih.gov/pubmed/30355602
http://dx.doi.org/10.1101/gr.235861.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280755/
https://www.ncbi.nlm.nih.gov/pubmed/30355602
http://dx.doi.org/10.1101/gr.235861.118

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