Cargando…
Ranking noncanonical 5′ splice site usage by genome-wide RNA-seq analysis and splicing reporter assays
Most human pathogenic mutations in 5′ splice sites affect the canonical GT in positions +1 and +2, leading to noncanonical dinucleotides. On the other hand, noncanonical dinucleotides are observed under physiological conditions in ∼1% of all human 5′ss. It is therefore a challenging task to understa...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280755/ https://www.ncbi.nlm.nih.gov/pubmed/30355602 http://dx.doi.org/10.1101/gr.235861.118 |