Longer TOMM40 poly-T variants associated with higher FDDNP-PET medial temporal tau and amyloid binding

BACKGROUND: The translocase of outer mitochondrial membrane 40 (TOMM40), which lies in linkage disequilibrium with the apolipoprotein E (APOE) gene, has been implicated in Alzheimer’s disease (AD). TOMM40 influences AD pathology through mitochondrial neurotoxicity, and the medial temporal lobe (MTL)...

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Detalles Bibliográficos
Autores principales: Siddarth, Prabha, Burggren, Alison C., Merrill, David A., Ercoli, Linda M., Mahmood, Zanjbeel, Barrio, Jorge R., Small, Gary W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281258/
https://www.ncbi.nlm.nih.gov/pubmed/30517207
http://dx.doi.org/10.1371/journal.pone.0208358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281258/
https://www.ncbi.nlm.nih.gov/pubmed/30517207
http://dx.doi.org/10.1371/journal.pone.0208358

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