Direct CNS delivery of proteins using thermosensitive liposome-in-gel carrier by heterotopic mucosal engrafting

Delivering therapeutics across the blood-brain barrier (BBB) for treating central nervous system (CNS) diseases is one of the biggest challenges today as the BBB limits the uptake of molecules greater than 500 Da into the CNS. Here we describe a novel trans-nasal mucosal drug delivery as an alternat...

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Detalles Bibliográficos
Autores principales: Pawar, Grishma N., Parayath, Neha N., Nocera, Angela L., Bleier, Benjamin S., Amiji, Mansoor M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281301/
https://www.ncbi.nlm.nih.gov/pubmed/30517163
http://dx.doi.org/10.1371/journal.pone.0208122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281301/
https://www.ncbi.nlm.nih.gov/pubmed/30517163
http://dx.doi.org/10.1371/journal.pone.0208122

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