The potential of substance P to initiate and perpetuate cortical spreading depression (CSD) in rat in vivo

The tachykinin substance P (SP) increases neuronal excitability, participates in homeostatic control, but induces brain oedema after stroke or trauma. We asked whether SP is able to induce cortical spreading depression (CSD) which often aggravates stroke-induced pathology. In anesthetized rats we ap...

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Detalles Bibliográficos
Autores principales: Richter, Frank, Eitner, Annett, Leuchtweis, Johannes, Bauer, Reinhard, Ebersberger, Andrea, Lehmenkühler, Alfred, Schaible, Hans-Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281573/
https://www.ncbi.nlm.nih.gov/pubmed/30518958
http://dx.doi.org/10.1038/s41598-018-36330-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281573/
https://www.ncbi.nlm.nih.gov/pubmed/30518958
http://dx.doi.org/10.1038/s41598-018-36330-2

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