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The potential of substance P to initiate and perpetuate cortical spreading depression (CSD) in rat in vivo
The tachykinin substance P (SP) increases neuronal excitability, participates in homeostatic control, but induces brain oedema after stroke or trauma. We asked whether SP is able to induce cortical spreading depression (CSD) which often aggravates stroke-induced pathology. In anesthetized rats we ap...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281573/ https://www.ncbi.nlm.nih.gov/pubmed/30518958 http://dx.doi.org/10.1038/s41598-018-36330-2 |