Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis

Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and senescence, restricting cartilage regeneration and favouring disease progression. Similar to...

Descripción completa

Detalles Bibliográficos
Autores principales: Varela-Eirín, Marta, Varela-Vázquez, Adrián, Guitián-Caamaño, Amanda, Paíno, Carlos Luis, Mato, Virginia, Largo, Raquel, Aasen, Trond, Tabernero, Arantxa, Fonseca, Eduardo, Kandouz, Mustapha, Caeiro, José Ramón, Blanco, Alfonso, Mayán, María D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281585/
https://www.ncbi.nlm.nih.gov/pubmed/30518918
http://dx.doi.org/10.1038/s41419-018-1225-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281585/
https://www.ncbi.nlm.nih.gov/pubmed/30518918
http://dx.doi.org/10.1038/s41419-018-1225-2

Ejemplares similares