A semi-supervised approach for predicting cell-type specific functional consequences of non-coding variation using MPRAs

Predicting the functional consequences of genetic variants in non-coding regions is a challenging problem. We propose here a semi-supervised approach, GenoNet, to jointly utilize experimentally confirmed regulatory variants (labeled variants), millions of unlabeled variants genome-wide, and more tha...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Zihuai, Liu, Linxi, Wang, Kai, Ionita-Laza, Iuliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281617/
https://www.ncbi.nlm.nih.gov/pubmed/30518757
http://dx.doi.org/10.1038/s41467-018-07349-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281617/
https://www.ncbi.nlm.nih.gov/pubmed/30518757
http://dx.doi.org/10.1038/s41467-018-07349-w

Ejemplares similares