Effective nose-to-brain delivery of exendin-4 via coadministration with cell-penetrating peptides for improving progressive cognitive dysfunction

In a recent study, we demonstrated the potential of a cell-penetrating peptide (CPP) penetratin to deliver the peptide drug insulin to the brain via nasal administration, and its pharmacological effect on the mild cognitive dysfunction in senescence-accelerated mouse (SAMP8). However, the therapeuti...

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Detalles Bibliográficos
Autores principales: Kamei, Noriyasu, Okada, Nobuyuki, Ikeda, Takamasa, Choi, Hayoung, Fujiwara, Yui, Okumura, Haruka, Takeda-Morishita, Mariko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281676/
https://www.ncbi.nlm.nih.gov/pubmed/30518944
http://dx.doi.org/10.1038/s41598-018-36210-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281676/
https://www.ncbi.nlm.nih.gov/pubmed/30518944
http://dx.doi.org/10.1038/s41598-018-36210-9

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