NF1 mutations are recurrent in adult acute myeloid leukemia and confer poor outcome

Targeted mutation assessment of 81 genes in 1,021 adults with de novo acute myeloid leukemia (AML) identified recurrent mutations in the neurofibromin 1 (NF1) gene in 52 (5.1%) patients, including 36 (5.2%) younger and 16 (4.8%) older patients, which suggests NF1 belongs to the 20 most frequently mu...

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Detalles Bibliográficos
Autores principales: Eisfeld, Ann-Kathrin, Kohlschmidt, Jessica, Mrózek, Krzysztof, Mims, Alice, Walker, Christopher J., Blachly, James S., Nicolet, Deedra, Orwick, Shelley, Maharry, Sophia E., Carroll, Andrew J., Powell, Bayard L., Kolitz, Jonathan E., Wang, Eunice S., Stone, Richard M., de la Chapelle, Albert, Byrd, John C., Bloomfield, Clara D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281863/
https://www.ncbi.nlm.nih.gov/pubmed/29872168
http://dx.doi.org/10.1038/s41375-018-0147-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281863/
https://www.ncbi.nlm.nih.gov/pubmed/29872168
http://dx.doi.org/10.1038/s41375-018-0147-4

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