Stargazer: a software tool for calling star alleles from next-generation sequencing data using CYP2D6 as a model

PURPOSE: Genotyping CYP2D6 is important for precision drug therapy because it metabolizes approximately 25% of drugs and its activity varies considerably among individuals. Genotype analysis of CYP2D6 is challenging due to its highly polymorphic nature. Over 100 haplotypes (star alleles) have been d...

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Detalles Bibliográficos
Autores principales: Lee, Seung-been, Wheeler, Marsha M., Patterson, Karynne, McGee, Sean, Dalton, Rachel, Woodahl, Erica L., Gaedigk, Andrea, Thummel, Kenneth E., Nickerson, Deborah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281872/
https://www.ncbi.nlm.nih.gov/pubmed/29875422
http://dx.doi.org/10.1038/s41436-018-0054-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281872/
https://www.ncbi.nlm.nih.gov/pubmed/29875422
http://dx.doi.org/10.1038/s41436-018-0054-0

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