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Stargazer: a software tool for calling star alleles from next-generation sequencing data using CYP2D6 as a model
PURPOSE: Genotyping CYP2D6 is important for precision drug therapy because it metabolizes approximately 25% of drugs and its activity varies considerably among individuals. Genotype analysis of CYP2D6 is challenging due to its highly polymorphic nature. Over 100 haplotypes (star alleles) have been d...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281872/ https://www.ncbi.nlm.nih.gov/pubmed/29875422 http://dx.doi.org/10.1038/s41436-018-0054-0 |