Cargando…

Human CD8(+)HLA-DR(+) Regulatory T Cells, Similarly to Classical CD4(+)Foxp3(+) Cells, Suppress Immune Responses via PD-1/PD-L1 Axis

We have previously identified a human CD8(+)HLA-DR(+) regulatory T cell subset with the ability to suppress proliferation of autologous PBMCs responder cells through cell contact and CTLA-4 co-inhibitory molecule. The present study characterizes the complete phenotype of CD8(+)HLA-DR(+) Treg cells w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Machicote, Andres, Belén, Santiago, Baz, Placida, Billordo, Luis A., Fainboim, Leonardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281883/ https://www.ncbi.nlm.nih.gov/pubmed/30555473 http://dx.doi.org/10.3389/fimmu.2018.02788

Ejemplares similares

Analysis of Suppressor and Non-Suppressor FOXP3+ T Cells in HIV-1-Infected Patients
por: Arruvito, Lourdes, et al.
Publicado: (2012)

Staphylococcus aureus convert neonatal conventional CD4(+) T cells into FOXP3(+) CD25(+) CD127(low) T cells via the PD-1/PD-L1 axis
por: Rabe, Hardis, et al.
Publicado: (2014)

Expression of TIGIT, PD-1 and HLA-DR/CD38 markers on CD8-T cells of children and adolescents infected with HIV and uninfected controls
por: Pereira-Manfro, Wânia Ferraz, et al.
Publicado: (2023)

Baseline immune signature score of Tregs × HLA-DR(+)CD4(+) T cells × PD1(+)CD8(+) T cells predicts outcome to immunotherapy in cancer patients
por: Mispelbaum, Rebekka, et al.
Publicado: (2022)

Characterization of tonsillar IL10 secreting B cells and their role in the pathophysiology of tonsillar hypertrophy
por: Sarmiento Varon, Lindybeth, et al.
Publicado: (2017)

Immunohistochemical Analysis of Foxp3(+), CD4(+), CD8(+) Cell Infiltrates and PD-L1 in Oral Squamous Cell Carcinoma
por: Stasikowska-Kanicka, Olga, et al.
Publicado: (2017)

CD4(+) and CD8(+) T cells in sentinel nodes exhibit distinct pattern of PD‐1, CD69, and HLA‐DR expression compared to tumor tissue in oral squamous cell carcinoma
por: Piersiala, Krzysztof, et al.
Publicado: (2021)

Autologous Dendritic Cell Therapy in Mesothelioma Patients Enhances Frequencies of Peripheral CD4 T Cells Expressing HLA-DR, PD-1, or ICOS
por: de Goeje, Pauline L., et al.
Publicado: (2018)

CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1(+) viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion
por: Correa-Rocha, Rafael, et al.
Publicado: (2018)

Prognostic value, localization and correlation of PD-1/PD-L1, CD8 and FOXP3 with the desmoplastic stroma in pancreatic ductal adenocarcinoma
por: Diana, Angela, et al.
Publicado: (2016)

PD-1/PD-L1 expression in a series of intracranial germinoma and its association with Foxp3+ and CD8+ infiltrating lymphocytes
por: Liu, Bin, et al.
Publicado: (2018)

Advances in CD30- and PD-1-targeted therapies for classical Hodgkin lymphoma
por: Wang, Yucai, et al.
Publicado: (2018)

Circulating memory PD-1(+)CD8(+) T cells and PD-1(+)CD8(+)T/PD-1(+)CD4(+)T cell ratio predict response and outcome to immunotherapy in advanced gastric cancer patients
por: Liu, Jiang, et al.
Publicado: (2023)

Variable density of CD8+ and CD25+ programmed cell death-1 (PD-1) ligand (PD-L1) CD4+ T cells within the tumor microenvironment causes differential responses to the PD-1/PD-L1 blockade
por: Wu, Si-Pei, et al.
Publicado: (2015)

Decreased blood CD4+PD-1+ and CD8+PD-1+ T cells in psoriatic patients with and without arthritis
por: Bartosińska, Joanna, et al.
Publicado: (2018)

The Clinical Features of Patients with Chronic Hepatitis C Virus Infections Are Associated with Killer Cell Immunoglobulin-Like Receptor Genes and Their Expression on the Surface of Natural Killer Cells
por: Podhorzer, Ariel, et al.
Publicado: (2018)

Characteristics and PD-1 expression of peripheral CD4(+)CD127(lo)CD25(hi)FoxP3(+ )Treg cells in chronic HCV infected-patients
por: Shen, Tao, et al.
Publicado: (2011)

Prognostic Relevance of CD4(+), CD8(+) and FOXP3(+) TILs in Oral Squamous Cell Carcinoma and Correlations with PD-L1 and Cancer Stem Cell Markers
por: Lequerica-Fernández, Paloma, et al.
Publicado: (2021)

Circulating Exhausted PD-1(+)CD39(+) Helper CD4 T Cells Are Tumor-Antigen-Specific and Predict Response to PD-1/PD-L1 Axis Blockade
por: Martinez-Gomez, Carlos, et al.
Publicado: (2022)

Circulating HLA-DR(+)CD4(+) effector memory T cells resistant to CCR5 and PD-L1 mediated suppression compromise regulatory T cell function in tuberculosis
por: Ahmed, Asma, et al.
Publicado: (2018)

PD-1 blockade restores helper activity of tumor-infiltrating, exhausted PD-1(hi)CD39(+) CD4 T cells
por: Balança, Camille-Charlotte, et al.
Publicado: (2021)

Chinese medicine Ginseng and Astragalus granules ameliorate autoimmune diabetes by upregulating both CD4+FoxP3+ and CD8+CD122+PD1+ regulatory T cells
por: Wang, Yeshu, et al.
Publicado: (2017)

PD-1/PD-L1 Control of Antigen-Specifically Activated CD4 T-Cells of Neonates
por: Majer, Christiane, et al.
Publicado: (2023)

CD19-CAR-T Cells Bearing a KIR/PD-1-Based Inhibitory CAR Eradicate CD19(+)HLA-C1(−) Malignant B Cells While Sparing CD19(+)HLA-C1(+) Healthy B Cells
por: Tao, Lei, et al.
Publicado: (2020)

CD8(+)PD-1(+) to CD4(+)PD-1(+) ratio (PERLS) is associated with prognosis of patients with advanced NSCLC treated with PD-(L)1 blockers
por: Duchemann, Boris, et al.
Publicado: (2022)

PD-1/PD-L1 Pathway Modulates Macrophage Susceptibility to Mycobacterium tuberculosis Specific CD8(+) T cell Induced Death
por: Suarez, Guadalupe Verónica, et al.
Publicado: (2019)

PD-1/PD-L1 Pathway: A Therapeutic Target in CD30+ Large Cell Lymphomas
por: Xie, Wei, et al.
Publicado: (2022)

Systemic CD4 Immunity and PD-L1/PD-1 Blockade Immunotherapy
por: Escors, David, et al.
Publicado: (2022)

PD-1(+)CD8(+) T Cells Proximal to PD-L1(+)CD68(+) Macrophages Are Associated with Poor Prognosis in Pancreatic Ductal Adenocarcinoma Patients
por: Yang, Xiaobao, et al.
Publicado: (2023)

Increased Abundances of CD16(+) Non-Classical Monocytes Accompany with Elevated Monocytic PD-L1 and CD4(+) T Cell Disturbances in Oropharyngeal Cancer
por: Idel, Christian, et al.
Publicado: (2022)

S216: CD47/PD-L1 BISPECIFIC ANTIBODY (IBI322) IN ANTI-PD-1 OR PD-L1 TREATMENT-RESISTANT CLASSICAL HODGKIN LYMPHOMA: A PHASE I STUDY
por: Zhang, Huilai, et al.
Publicado: (2023)

Accumulation of CD5(+)CD19(+) B lymphocytes expressing PD-1 and PD-1L in hypertrophied pharyngeal tonsils
por: Wlasiuk, Paulina, et al.
Publicado: (2015)

CD4(+)FOXP3(+) Regulatory T Cell Therapies in HLA Haploidentical Hematopoietic Transplantation
por: Mancusi, Antonella, et al.
Publicado: (2019)

CD160-Associated CD8 T-Cell Functional Impairment Is Independent of PD-1 Expression
por: Viganò, Selena, et al.
Publicado: (2014)

The identification and functional analysis of CD8+PD-1+CD161+ T cells in hepatocellular carcinoma
por: Li, Zhixuan, et al.
Publicado: (2020)

Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade
por: Banchereau, Romain, et al.
Publicado: (2021)

CD39(+)PD-1(+)CD8(+) T cells mediate metastatic dormancy in breast cancer
por: Tallón de Lara, Paulino, et al.
Publicado: (2021)

Restored CD8(+)PD-1(+) T Cells Facilitate the Response to Anti-PD-1 for Patients With Pancreatic Ductal Adenocarcinoma
por: Zhu, Qian, et al.
Publicado: (2022)

Neuropilin-1 cooperates with PD-1 in CD8(+) T cells predicting outcomes in melanoma patients treated with anti-PD1
por: Rossignol, Julien, et al.
Publicado: (2022)

Peripheral tolerance induced by apoptotic cells and PD-1+ CD8 T cells
por: Kazama, Hirotaka, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_cvmk6q0ktlva4e8qmapkjhspj4